Selank 10mg — Anxiolytic Nootropic Peptide | Research Compound

Selank (TBCK-acetyl-Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic stabilized analogue of tuftsin, a naturally occurring tetrapeptide with immunomodulatory activity. Originally developed by the Institute of Molecular Genetics of the Russian Academy of Sciences, Selank has been extensively investigated for its anxiolytic, nootropic, and neuroprotective effects — with a profile that distinguishes it mechanistically from classical benzodiazepine-based anxiolytics. It acts without sedation, dependence potential, or significant peripheral side effects in preclinical models, making it a valuable research tool in neuropharmacology.

Research Background

Selank’s primary mechanism involves modulation of the GABAergic system and upregulation of BDNF (brain-derived neurotrophic factor) expression, alongside effects on serotonin metabolism, enkephalin degradation inhibition, and IL-6 cytokine activity. Preclinical data suggest it potentiates inhibitory neurotransmission in a manner analogous to anxiolytics, while simultaneously enhancing memory consolidation and cognitive flexibility — a combination rarely observed in single compounds. Its tuftsin backbone also confers immunomodulatory activity, making it of interest in neuroimmunology research.

Key Research Areas

• Anxiolytic pharmacology: Investigating GABAergic and serotonergic modulation in stress and anxiety models without the sedative or tolerance-inducing profile of classical benzodiazepines
• Nootropic mechanisms: Studying effects on working memory, learning acquisition, and BDNF upregulation in hippocampal and cortical preparations
• Neuroprotection: Examining Selank’s capacity to attenuate neuroinflammation and oxidative stress in CNS injury and neurodegeneration models
• Neuroimmunology: Exploring tuftsin receptor-mediated immunomodulation and cytokine regulation (IL-6, TNF-α) in the context of neuroinflammatory disease models
• Enkephalin system: Characterizing inhibition of enkephalin-degrading enzymes and downstream opioidergic effects on mood and analgesia research models

Product Specifications

• Compound: Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro acetate)
• Quantity: 10 mg per vial
• Form: Lyophilized powder
• Purity: ≥98% (HPLC)
• Storage: Store at −20°C, protected from light and moisture
• Reconstitution: Reconstitute in sterile bacteriostatic water per standard laboratory protocol

Frequently Asked Questions

How does Selank differ from classical anxiolytic compounds used in research?
Benzodiazepines and barbiturates act as positive allosteric modulators at the GABA-A receptor with broad CNS depression. Selank modulates GABAergic tone through a distinct mechanism — potentially via regulation of GABAergic interneuron activity — while simultaneously upregulating BDNF and inhibiting enkephalin breakdown. This produces an anxiolytic-like profile in rodent models without the sedation, ataxia, or receptor downregulation typically associated with GABA-A positive modulators.

What is the relationship between Selank and tuftsin?
Tuftsin is a naturally occurring tetrapeptide (Thr-Lys-Pro-Arg) derived from the Fc region of IgG, known primarily for its immunostimulant and phagocytosis-enhancing activity. Selank was engineered by extending the tuftsin sequence with Pro-Gly-Pro and adding a stabilizing N-terminal modification to increase metabolic half-life, enabling CNS activity alongside preserved immunomodulatory properties.

What in vitro and in vivo models are most relevant for Selank research?
Common in vivo models include the elevated plus maze, open field test, and forced swim test for anxiolytic/antidepressant characterization; Morris water maze and novel object recognition for cognitive endpoints; and LPS-induced neuroinflammation models for neuroimmune studies. In vitro: primary hippocampal neurons, BV-2 microglia, and SH-SY5Y cell lines are frequently used.

Is this product intended for human use?
No. Selank is sold strictly for in vitro and in vivo laboratory research use only. It is not approved for human or veterinary administration, and Webber Science makes no claims regarding its safety or efficacy in humans.

This product is intended for research purposes only. Not for human or veterinary use. Must be handled by qualified researchers in accordance with applicable regulations.